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Iron is the most abundant transition metal in biology and an essential cofactor for many cellular enzymes.
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Previously we have shown by electron microscopy that the extracellular domain of siv gp41 which is analogous to that of hiv forms high molecular weight aggregates in vitro and we have postulated that such high molecular weight aggregates are responsible for.
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During the past years much effort has been paid to understand the molecular mechanism involved in maintaining systemic iron homeostasis in mammals.
Interacts with integrin alpha 4 beta 1 itga4 itgb1 on leukocytes and mediates both adhesion and signal transduction.
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Iron is the most abundant transition metal in biology and an essential cofactor for many cellular enzymes.
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Iron homeostasis impairment is also a component of peripheral neuropathies.
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The vcam1 itga4 itgb1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Iron homeostasis impairment is also a component of peripheral neuropathies.
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Important in cell cell recognition.
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